Catechol-O-methyltransferase association with hemoglobin A1c
نویسندگان
چکیده
منابع مشابه
Association between Catechol-O-Methyltransferase Gene Variant and Bipolar Disorder
Emotional dysregulation is a core characteristic of many psychiatric diseases. Bipolar disorder is a brain disorder that causes unusual shifts in mood, energy level, activity level and ability to carry day to day work. CatecholO-methyltransferase (COMT) is involved in the metabolism of dopamine and epinephrine. To a large extent it is responsible in maintaining human cognitive functioning. Poly...
متن کاملMetabolism of catechol estrogens by erythrocyte catechol-O methyltransferase.
Fishman and Tulchinsky (1) present evidence that the catechol estrogen 2hydroxyestrone suppresses serum prolactin in normal ovulatory young women. However, in 3 of the 12 subjects studied the authors were unable to suppress serum prolactin and suggested that prolactin response to 2-hydroxyestrone is subjectand not time-dependent. In a study designed to evaluate the kinetics of catechol estrogen...
متن کاملCatechol-O-Methyltransferase in Parkinson’s Disease
The introduction of levodopa therapy for Parkinson’s disease (PD), initially by Birkmayer and colleagues in 1961 and Barbeau and colleagues in 1962, and in its ultimately successful form by Cotzias and colleagues in 1967, still represents the defining landmark in the treatment of PD (1–3). This dramatic advance was preceded by methodical basic laboratory research in the late 1950s and early 196...
متن کاملCatechol-O-methyltransferase and Parkinson's disease.
Parkinson's disease (PD) is one of the main causes of neurological disability in the elderly. Levodopa is the gold standard for treating this disease, but chronic levodopa therapy is complicated by motor fluctuation and dyskinesia. The catechol-O-methyltransferase (COMT) inhibitors represent a new class of antiparkinsonian drugs. When coadministered with levodopa/decarboxylase inhibitor, 2 COMT...
متن کاملLack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase.
OBJECTIVE To test whether variation in the gene encoding the enzyme catechol-O-methyltransferase (COMT), which catalyzes the breakdown of dopamine and other catecholamine neurotransmitters, is associated with the risk for alcohol dependence and habitual smoking. METHODS Single nucleotide polymophisms (SNPs) were genotyped in a sample of 219 multiplex alcohol-dependent families of European Ame...
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ژورنال
عنوان ژورنال: Metabolism
سال: 2016
ISSN: 0026-0495
DOI: 10.1016/j.metabol.2016.04.001